vision/eye
• shorter outer segments than in wild-type at 4 and 24 weeks of age
|
• thinner inner nuclear layer with reduced cell counts than in wild-type at 24 weeks of age
|
• thinner outer nuclear layer with fewer nuclei than in wild-type at 4 and 24 weeks of age
|
• decrease in rod function that worsens with increasing age and is followed by a reduction of cone function
|
• photopic b-waves are smaller than in wild-type at later ages (24-32 weeks) but not at early ages (4 weeks)
• photopic b-wave amplitudes decrease much later than the decrease in the scotopic b-wave amplitudes
|
• scotopic a- and b-waves are smaller than in wild-type at later ages (24-32 weeks) but not at early ages (4 weeks)
|
nervous system
• shorter outer segments than in wild-type at 4 and 24 weeks of age
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
retinitis pigmentosa 30 | DOID:0110406 |
OMIM:607921 |
J:103713 |