Phenotypes Associated with This Genotype

Genotype
MGI:3614341

• Allelic Composition: Tg(MMTV-PyVT*Y250F)250-2Mul/?
• Genetic Background: FVB/N-Tg(MMTV-PyVT*Y250F)250-2Mul

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

mammary gland alveolar hyperplasia ( J:56327 )

♀ • female specific phenotype, global induction of well-defined alveolar hyperplasia in 12-week-old virgin animals

♀ • the mammary epithelium were incapable of nursing

increased mammary adenocarcinoma incidence ( J:56327 )

• female specific phenotype, extensive mammary epithelial hyperplasias eventually developed mammary tumors with 100% penetrance

• compared to transgenic mice expressing wild-type plyomavirus middle T antigen, there was a significant delay in induction of tumors

• the tumors were focal in origin and contain a large stromal component

neoplasm

increased mammary adenocarcinoma incidence ( J:56327 )

• female specific phenotype, extensive mammary epithelial hyperplasias eventually developed mammary tumors with 100% penetrance

• compared to transgenic mice expressing wild-type plyomavirus middle T antigen, there was a significant delay in induction of tumors

• the tumors were focal in origin and contain a large stromal component

integument

mammary gland alveolar hyperplasia ( J:56327 )

♀ • female specific phenotype, global induction of well-defined alveolar hyperplasia in 12-week-old virgin animals

♀ • the mammary epithelium were incapable of nursing

increased mammary adenocarcinoma incidence ( J:56327 )

• female specific phenotype, extensive mammary epithelial hyperplasias eventually developed mammary tumors with 100% penetrance

• compared to transgenic mice expressing wild-type plyomavirus middle T antigen, there was a significant delay in induction of tumors

• the tumors were focal in origin and contain a large stromal component

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:56327