Phenotypes Associated with This Genotype

Genotype
MGI:3614342

• Allelic Composition: Tg(MMTV-PyVT*Y315F*Y322F)Db-1Mul/?
• Genetic Background: FVB/N-Tg(MMTV-PyVT*Y315F*Y322F)Db-1Mul

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:56327 )

♀ • female specific phenotype, extensive mammary epithelial hyperplasias eventually developed mammary tumors with 100% penetrance

♀ • compared to transgenic mice expressing wild-type plyomavirus middle T antigen, there was a significant delay in induction of tumors

♀ • the tumors appeared to be less differentiated than tumors expressing wild-type plyomavirus middle T antigen or mutant plyomavirus middle T antigen with Y to F mutation at position 250

mammary gland hyperplasia ( J:56327 )

♀ • female specific phenotype, global induction of extremely cystic and dilated mammary epithelial hyperplasia without defined alveolar structures in 12-week-old virgin animals

♀ • the mammary epithelium were incapable of nursing

increased mammary gland apoptosis ( J:56327 )

♀ • mammary epithelial hyperplasias displayed extensive apoptotic cell death

neoplasm

increased mammary adenocarcinoma incidence ( J:56327 )

♀ • female specific phenotype, extensive mammary epithelial hyperplasias eventually developed mammary tumors with 100% penetrance

♀ • compared to transgenic mice expressing wild-type plyomavirus middle T antigen, there was a significant delay in induction of tumors

♀ • the tumors appeared to be less differentiated than tumors expressing wild-type plyomavirus middle T antigen or mutant plyomavirus middle T antigen with Y to F mutation at position 250

integument

increased mammary adenocarcinoma incidence ( J:56327 )

♀ • female specific phenotype, extensive mammary epithelial hyperplasias eventually developed mammary tumors with 100% penetrance

♀ • compared to transgenic mice expressing wild-type plyomavirus middle T antigen, there was a significant delay in induction of tumors

♀ • the tumors appeared to be less differentiated than tumors expressing wild-type plyomavirus middle T antigen or mutant plyomavirus middle T antigen with Y to F mutation at position 250

mammary gland hyperplasia ( J:56327 )

♀ • female specific phenotype, global induction of extremely cystic and dilated mammary epithelial hyperplasia without defined alveolar structures in 12-week-old virgin animals

♀ • the mammary epithelium were incapable of nursing

increased mammary gland apoptosis ( J:56327 )

♀ • mammary epithelial hyperplasias displayed extensive apoptotic cell death

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:56327