Phenotypes Associated with This Genotype

Genotype
MGI:3614439

• Allelic Composition: Kiss1r^tm1Gstn/Kiss1r^tm1Gstn
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

reproductive system phenotype ( J:102113 )

N • examination of homozygous embryos at 16.5 dpc shows no differences in the development of the reproductive organs compared to wild-type suggesting that the appearance of the following phenotypes at 7 weeks of age is a postnatal event

abnormal female reproductive system morphology ( J:102113 )

♀

small ovary ( J:102113 )

♀

small uterine cervix ( J:102113 )

♀ • reduced in size or not found due to small size

small uterus ( J:102113 )

♀

uterus hypoplasia ( J:102113 )

♀ • hypoplasia of uterine horns

small vagina ( J:102113 )

♀ • reduced in size or not found due to small size

abnormal male reproductive system morphology ( J:102113 )

♂

absent male preputial gland ( J:102113 )

♂ • frequently absent

absent prostate gland ( J:102113 )

♂

absent seminal vesicle ( J:102113 )

♂

small seminiferous tubules ( J:102113 )

♂

decreased Leydig cell number ( J:102113 )

♂

decreased testis weight ( J:102113 )

♂ • 17% reduction in testis weight

small penis ( J:102113 )

♂

small epididymis ( J:102113 )

♂

abnormal fertility/fecundity ( J:102113 )

female infertility ( J:102113 )

♀

male infertility ( J:102113 )

♂

growth/size/body

decreased body weight ( J:102113 )

• males exhibit lower body weight than controls

immune system

increased thymus weight ( J:102113 )

• higher thymus/body weight ratio

renal/urinary system

absent male preputial gland ( J:102113 )

♂ • frequently absent

decreased kidney weight ( J:102113 )

• reduced kidney/body weight ratio

small penis ( J:102113 )

♂

endocrine/exocrine glands

increased thymus weight ( J:102113 )

• higher thymus/body weight ratio

mammary gland hypoplasia ( J:102113 )

♀

absent male preputial gland ( J:102113 )

♂ • frequently absent

absent prostate gland ( J:102113 )

♂

absent seminal vesicle ( J:102113 )

♂

small ovary ( J:102113 )

♀

small seminiferous tubules ( J:102113 )

♂

decreased Leydig cell number ( J:102113 )

♂

decreased testis weight ( J:102113 )

♂ • 17% reduction in testis weight

hematopoietic system

increased thymus weight ( J:102113 )

• higher thymus/body weight ratio

integument

mammary gland hypoplasia ( J:102113 )

♀

absent male preputial gland ( J:102113 )

♂ • frequently absent

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hypogonadotropic hypogonadism 8 with or without anosmia		DOID:0090074	OMIM:614837	J:102113