Analysis Tools
cardiovascular system
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• recruitment of neutrophils during reperfusion is reduced, with reduced leukocyte adhesion to the inner vessel wall of postcapillary venules and reduced number of transmigrated leukocytes
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immune system
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• at 120 min of reperfusion, show a 48.5% reduction in the number of transmigrated leukocytes compared to wild-type, however leukocyte extravascular migration distances are comparable to wild-type
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• at 5 min of reperfusion, significantly fewer leukocytes adhere to the inner vessel wall of postcapillary venules than in wild-type, however no differences are seen with respect to then number of rolling leukocytes
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• survival of transplated cardiac allographs from BALB/c mice into homozygotes is significantly increased and allografts show less tissue remodeling and hence better preservation of myocardial architecture
• carotid artery allografts from BALB/c mice into homozygotes show better tissue preservation and significant reduction of neointima formation and CD3+ T cell infiltration
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homeostasis/metabolism
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• recruitment of neutrophils during reperfusion is reduced, with reduced leukocyte adhesion to the inner vessel wall of postcapillary venules and reduced number of transmigrated leukocytes
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cellular
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• at 120 min of reperfusion, show a 48.5% reduction in the number of transmigrated leukocytes compared to wild-type, however leukocyte extravascular migration distances are comparable to wild-type
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• at 5 min of reperfusion, significantly fewer leukocytes adhere to the inner vessel wall of postcapillary venules than in wild-type, however no differences are seen with respect to then number of rolling leukocytes
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hematopoietic system
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• at 120 min of reperfusion, show a 48.5% reduction in the number of transmigrated leukocytes compared to wild-type, however leukocyte extravascular migration distances are comparable to wild-type
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• at 5 min of reperfusion, significantly fewer leukocytes adhere to the inner vessel wall of postcapillary venules than in wild-type, however no differences are seen with respect to then number of rolling leukocytes
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