Phenotypes Associated with This Genotype

Genotype
MGI:3615785

• Allelic Composition: Cat^b/Cat^b
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating cholesterol level ( J:5205 , J:5351 )

• average serum cholesterol is approximately 94 mg/kg instead of 111.6 mg/kg in control mice (J:5205)

decreased circulating triglyceride level ( J:5205 , J:5351 )

• serum triglyceride levels are much lower than normal (J:5205)

abnormal catalase activity ( J:5015 , J:105024 )

• blood catalase activity in homozygotes is generally below 10 perborate units per ml of whole blood (J:5015)

• very low catalase activity in blood (1.1.-2.4 PU/ml) as compared to wildtype Cat^a mice (144-155 PU/ml) (J:105024)

• catalase activity in liver (21-28 PU/gm), kidney (6.0-8.7PU/gm), lung (12-17 PU/gm), and intestine (18-19 PU/gm) is lower than wild-type Cat^a mice (J:105024)

• catalase activity in stomach (26 PU/gm) and brain (37-40 PU/gm) is higher than wild-type Cat^a mice (J:105024)

• catalase activity in liver and kidney exhibits increased sensitivity to the inhibitory agents guanidine, urea , and aminotriazole relative to wild-type (J:105024)

• catalase activity in liver and kidney exhibits decreased sensitivity to the inhibitory agent azide relative to wild-type (J:105024)

cellular

abnormal redox activity ( J:105024 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	acatalasia	DOID:2582	OMIM:614097	J:105024