Phenotypes Associated with This Genotype

Genotype
MGI:3615834

• Allelic Composition: Nbn^tm1Jpt/Nbn^tm1Jpt
• Genetic Background: involves: 129S7/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

cellular phenotype ( J:144172 )

N • mice exhibit normal ionizing radiation-induced apoptosis in the developing nervous system and cultured thymocytes

abnormal cell cycle checkpoint function ( J:75956 )

• MEFs exhibit defective intra S phase and G2/M checkpoints after ionizing radiation treatment

increased cellular sensitivity to gamma-irradiation ( J:75956 )

• MEFs exhibit pronounced sensitivity to ionizing radiation

chromosome breakage ( J:75956 )

• significantly higher levels of chromosomal aberrations following ionizing radiation treatment than wild-type, exhibiting increases in both deletion and exchange type aberrations

immune system

immune system phenotype ( J:75956 )

N • immunoglobulin isotype profiles are indistinguishable from controls and splenic B and thymic T cell propulations vary by less than 25% from wild-type

reproductive system

reproductive system phenotype ( J:75956 )

N • male and females are fertile and exhibit no abnormalities in ovaries or testes

neoplasm

neoplasm ( J:75956 )

N • homozygotes are not markedly prone to malignancy

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Nijmegen breakage syndrome		DOID:7400	OMIM:251260	J:75956