Phenotypes Associated with This Genotype

Genotype
MGI:3617910

• Allelic Composition: Sall4^Gt(XE027)Byg/Sall4⁺
• Genetic Background: involves: 129P2/OlaHsd * Black Swiss * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis ( J:105332 )

• Background Sensitivity: the severity of defects is increased when crossed into a Black Swiss background

cardiovascular system

disorganized myocardium ( J:105332 )

• in less severe cases the myocardium is disorganized

thin myocardium ( J:105332 )

• in severe cases a univentricular heart is present with thin myocardium

abnormal heart development ( J:105332 )

• at E9.5 in severely affected embryos defects in cardiac patterning can be seen including decreased expression of Gja5 and expansion of the left ventricular marker Nppa across the interventricular groove

muscular ventricular septal defect ( J:105332 )

• heterozygotes that survive past E11.5 often have ventricular septal defects

common ventricle ( J:105332 )

• in severe cases a univentricular heart is present with thin myocardium

abnormal interventricular groove morphology ( J:105332 )

• the interventricular groove is less pronounced or in severe cases absent

muscle

disorganized myocardium ( J:105332 )

• in less severe cases the myocardium is disorganized

thin myocardium ( J:105332 )

• in severe cases a univentricular heart is present with thin myocardium

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Duane-radial ray syndrome		DOID:0060747	OMIM:607323	J:105332