Phenotypes Associated with This Genotype

Genotype
MGI:3617977

• Allelic Composition: Stat4^tm1Gru/Stat4^tm1Gru
• Genetic Background: C.129S2-Stat4^tm1Gru

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal CD4-positive T cell differentiation ( J:143729 )

• mutant polarized Th17 CD4⁺ T cells fail to convert to the Th1-like state in the presence of IL-12

• wild-type CD4⁺ T cells polarized under Th17 conditions can be converted to a Th1-like cells (i.e. they express IFN-gamma) by culturing with IL-12

decreased circulating interferon-gamma level ( J:90600 )

• reduction in the serum level of IFNG are seen compared to levels in diabetic and non-diabetic NOD mice, but serum level is comparable to that in Stat4-null NOD mice

decreased circulating interleukin-2 level ( J:90600 )

• reduction in the serum level of IL-2 is seen compared to level in diabetic and non-diabetic NOD mice, but serum level of IL-12 is comparable to that of Stat4-null NOD mice

homeostasis/metabolism

decreased circulating interferon-gamma level ( J:90600 )

• reduction in the serum level of IFNG are seen compared to levels in diabetic and non-diabetic NOD mice, but serum level is comparable to that in Stat4-null NOD mice

decreased circulating interleukin-2 level ( J:90600 )

• reduction in the serum level of IL-2 is seen compared to level in diabetic and non-diabetic NOD mice, but serum level of IL-12 is comparable to that of Stat4-null NOD mice

hematopoietic system

abnormal CD4-positive T cell differentiation ( J:143729 )

• wild-type CD4⁺ T cells polarized under Th17 conditions can be converted to a Th1-like cells (i.e. they express IFN-gamma) by culturing with IL-12

• mutant polarized Th17 CD4⁺ T cells fail to convert to the Th1-like state in the presence of IL-12

renal/urinary system

abnormal kidney physiology ( J:84825 )

• onset of ischemia effects is delayed

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:106340