Phenotypes Associated with This Genotype

Genotype
MGI:3618361

cn3

• Allelic Composition: Ctnnd1^tm1Abre/Ctnnd1^tm1Abre; Tg(MMTV-cre)FMam/0
• Genetic Background: involves: 129S6/SvEvTac * Black Swiss * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:105283 )

• death occurs shortly after birth

digestive/alimentary system

abnormal major salivary gland morphology ( J:105283 )

• complete loss of exocrine acini in both the submandibular and sublingual glands

• both glands composed entirely of misshapen ducts

• foci present in which the epithelial structure of the ducts is completely disrupted

• foci expand from E14 to birth with all ducts eventually becoming occluded by large epithelial masses protruding into the lumen

• tube morphogenesis defective

abnormal sublingual gland morphology ( J:105283 )

abnormal submandibular gland morphology ( J:105283 )

abnormal submandibular gland physiology ( J:105283 )

• proliferating epithelial cells persist

increased submandibular gland apoptosis ( J:105283 )

• rates of apoptosis as much as 10X greater than controls

vision/eye

abnormal lacrimal gland morphology ( J:105283 )

• epithelia lack a prominent basal lamina

• collapsed lumina

• loss of cells and nuclear polarity

• cells with vacuolated cytoplasm

• poor cell-cell adhesion

endocrine/exocrine glands

abnormal major salivary gland morphology ( J:105283 )

• complete loss of exocrine acini in both the submandibular and sublingual glands

• both glands composed entirely of misshapen ducts

• foci present in which the epithelial structure of the ducts is completely disrupted

• foci expand from E14 to birth with all ducts eventually becoming occluded by large epithelial masses protruding into the lumen

• tube morphogenesis defective

abnormal sublingual gland morphology ( J:105283 )

abnormal submandibular gland morphology ( J:105283 )

abnormal submandibular gland physiology ( J:105283 )

• proliferating epithelial cells persist

increased submandibular gland apoptosis ( J:105283 )

• rates of apoptosis as much as 10X greater than controls

abnormal lacrimal gland morphology ( J:105283 )

• epithelia lack a prominent basal lamina

• collapsed lumina

• loss of cells and nuclear polarity

• cells with vacuolated cytoplasm

• poor cell-cell adhesion

cellular

increased submandibular gland apoptosis ( J:105283 )

• rates of apoptosis as much as 10X greater than controls