Phenotypes Associated with This Genotype

Genotype
MGI:3618695

• Allelic Composition: Tg(TcrbAI4)1Dvs/0
• Genetic Background: NOD-Tg(TcrbAI4)1Dvs

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal CD4-positive, alpha beta T cell morphology ( J:93553 )

• T cells expressing the transgene comprise ~22% of the total peripheral blood lymphocyte population, a significantly higher fraction of these T cells resides in the CD4 lineage rather than in the expected CD8 lineage

homeostasis/metabolism

abnormal circulating glucose level ( J:93553 )

• female NOD mice carrying this transgene exhibit a significantly reduced frequency and rate of development of IDDM

immune system

abnormal CD4-positive, alpha beta T cell morphology ( J:93553 )

• T cells expressing the transgene comprise ~22% of the total peripheral blood lymphocyte population, a significantly higher fraction of these T cells resides in the CD4 lineage rather than in the expected CD8 lineage

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	type 1 diabetes mellitus	DOID:9744	OMIM:222100	J:93553