Phenotypes Associated with This Genotype

Genotype
MGI:3618697

• Allelic Composition: Tg(TcraAI4)1Dvs/0
• Genetic Background: NOD-Tg(TcraAI4)1Dvs

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal CD4-positive, alpha beta T cell morphology ( J:93553 )

• T cells expressing the transgene comprise ~30% of the total peripheral blood lymphocyte population, a significantly higher fraction of these T cells resides in the CD4 lineage rather than in the expected CD8 lineage

immune system

abnormal CD4-positive, alpha beta T cell morphology ( J:93553 )

• T cells expressing the transgene comprise ~30% of the total peripheral blood lymphocyte population, a significantly higher fraction of these T cells resides in the CD4 lineage rather than in the expected CD8 lineage

increased susceptibility to autoimmune diabetes ( J:93553 )

• female NOD mice carrying this transgene develop IDDM at a slightly but not significantly accelerated rate compared to nontransgenic NOD controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:93553