Phenotypes Associated with This Genotype

Genotype
MGI:3618703

• Allelic Composition: B2m^tm1Unc/B2m^tm1Unc; Tg(TcraAI4)1Dvs/0; Tg(TcrbAI4)1Dvs/0
• Genetic Background: NOD.Cg-B2m^tm1Unc Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal CD8-positive, alpha beta T cell morphology ( J:93553 )

• mice exhibit a complete absence of CD8 T cells expressing the transgenes but transgene-expressing CD4 T cells are present

immune system

abnormal CD8-positive, alpha beta T cell morphology ( J:93553 )

• mice exhibit a complete absence of CD8 T cells expressing the transgenes but transgene-expressing CD4 T cells are present

decreased susceptibility to autoimmune diabetes ( J:93553 )

• B2m-deficient female transgenic NOD mice are completely diabetes resistant compared to transgenic NOD controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	type 1 diabetes mellitus	DOID:9744	OMIM:222100	J:93553