Phenotypes Associated with This Genotype

Genotype
MGI:3618724

• Allelic Composition: Nos3^tm1Gdk/Nos3^tm1Gdk
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

decreased heart rate ( J:46061 )

hypertension ( J:46061 )

• mean arterial blood pressure measured under urethane anesthesia is increased by 28 mm Hg, however do not observe cardiac hypertrophy

increased vasoconstriction ( J:46061 )

• intracoronary infusion of acetylcholine results in even more pronounced vasoconstriction than seen in wild-type, resulting in a flow decrease by 71%, however vasodilation was unaffected

muscle

increased vasoconstriction ( J:46061 )

• intracoronary infusion of acetylcholine results in even more pronounced vasoconstriction than seen in wild-type, resulting in a flow decrease by 71%, however vasodilation was unaffected

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
essential hypertension		DOID:10825	OMIM:145500 OMIM:603918 OMIM:604329 OMIM:607329 OMIM:608742 OMIM:610261 OMIM:610262 OMIM:610948 OMIM:611014	J:46061