Phenotypes Associated with This Genotype

Genotype
MGI:3618814

• Allelic Composition: Tg(H2-Ea^d)5Lt/0
• Genetic Background: NOD/ShiLt-Tg(H2-Ea^d)5Lt

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

periinsulitis ( J:36435 )

• pancreata of males and female show peri-insulitis

decreased interferon-gamma secretion ( J:36435 )

• GAD65-reactive T cells from transgenic mice produce significantly lower levels of IFNG than those from NOD controls

increased interleukin-4 secretion ( J:36435 )

• IL-4 levels produced by GAD65 responsive T cells of transgenic mice are 9-fold higher compared to NOD controls

autoimmune response ( J:36435 )

• transgenic mice develop autoimmune pathologies against salivary gland, thyroid and kidney comparable to conrol NOD mice, but no islet-directed autoimmune response is observed

decreased susceptibility to autoimmune diabetes ( J:36435 )

• no males or females develop diabetes (blood glucose >300 mg/dl) during the 40 week evaluation period compared to 60% and 90% incidence in non-transgenic NOD male and female controls respectively

• transgenic mice are almost completely resistant to cyclophosphamide-accelerated diabetes unlike NOD controls

endocrine/exocrine glands

periinsulitis ( J:36435 )

• pancreata of males and female show peri-insulitis

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	type 1 diabetes mellitus	DOID:9744	OMIM:222100	J:36435