Phenotypes Associated with This Genotype

Genotype
MGI:3618925

• Allelic Composition: Tg(Ins2-NP)25-3Olds/0
• Genetic Background: involves: BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating glucose level ( J:81284 , J:81287 )

• 3% of transgenic mice develop diabetes when followed for 10-12 months (J:81284)

• 93% of transgenic mice develop diabetes (hyperglycemia of >250 mg/dl glucose and islets infiltrated with mononuclear cells) after being infected with LCMV (J:81284)

• mice are considered diabetic after a blood glucose measure of >300 mg/dl (J:81287)

decreased circulating insulin level ( J:81287 )

• hypoinsulinemia is exhibited by transgenic mice accompanying increased glucose levels and islet infiltration

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:81284 , J:81287 )

• pancreata of diabetic transgenic mice show swollen islets with a ground glass appearance (J:81284)

• mononuclear cells begin infiltrating the islets 10 days after viral challenge and are apparent in most transgenic mice after 30 days (J:81284)

• Background Sensitivity: after viral challenge, mononuclear cells infiltrate the islets of transgenic mice bred onto a BALB/c background at 14-21days, while mice bred onto a C57BL/6 background show infiltrates at 21-60 days (J:81284)

immune system

decreased susceptibility to autoimmune diabetes ( J:81287 )

• depletion of CD8+ lymphocytes with a monoclonal antibody inhibited development of diabetes

increased susceptibility to autoimmune diabetes ( J:81287 )

• 3% of transgenic mice develop diabetes when followed for 10-12 months

• 93% of transgenic mice develop diabetes (evidenced by hyperglycemia with glucose levels of >300 mg/dl and islets infiltrated with mononuclear cells) after being infected with LCMV

• Background Sensitivity: after viral (LCMV) challenge, transgenic mice bred onto a C57BL/6 background develop diabetes in 3-5 months, whereas transgenic mice bred onto a BALB/c background develop diabetes sooner, at 1-2 months

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:81284