Phenotypes Associated with This Genotype

Genotype
MGI:3618987

• Allelic Composition: Tg(Ins2-GP)34-20Olds/0
• Genetic Background: involves: BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating glucose level ( J:81287 )

• mice are considered diabetic after a blood glucose measure of >300 mg/dl

decreased circulating insulin level ( J:81287 )

• hypoinsulinemia is exhibited by transgenic mice accompanying increased glucose levels and islet infiltration

immune system

abnormal lymphocyte physiology ( J:81287 )

• on a B6 background, transgenic mice cannot exhibit a primary CTL response

abnormal T cell physiology ( J:81287 )

• depletion of CD8+ lymphocytes with a monoclonal antibody inhibited development of diabetes

increased susceptibility to autoimmune diabetes ( J:81287 )

• mice rapidly develop diabetes (glucose levels >300 mg/dl) 10-14 days after viral (LCMV) challenge

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:81287 )

• mononuclear cells infiltrate the islets of transgenic mice 5-10 days after viral innoculation

absent pancreatic beta cells ( J:81287 )

• no beta cells are detected at 14 days after LCMV infection

hematopoietic system

abnormal lymphocyte physiology ( J:81287 )

• on a B6 background, transgenic mice cannot exhibit a primary CTL response

abnormal T cell physiology ( J:81287 )

• depletion of CD8+ lymphocytes with a monoclonal antibody inhibited development of diabetes

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:81287