Phenotypes Associated with This Genotype

Genotype
MGI:3619238

• Allelic Composition: Kcnab2^tm1Kmc/Kcnab2^tm1Kmc
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:75891 )

• Background Sensitivity: average life span about 255 days on mixed background

behavior/neurological

behavior/neurological phenotype ( J:167856 )

N • mice exhibit normal locomotion, anxiety-related behavior, and auditory response

abnormal learning/memory/conditioning ( J:167856 )

• mice exhibit impaired associative learning compared with wild-type mice

impaired contextual conditioning behavior ( J:167856 )

abnormal spatial learning ( J:167856 )

• in a Morris water maze, mice exhibit a non-selective search strategy compared with wild-type mice

• however, sensory motor function in a Morris water maze is normal

tremors ( J:75891 )

• Background Sensitivity: induced by swimming in cold water (17C) but not by swimming in warm water (37C)

sporadic seizures ( J:75891 )

nervous system

sporadic seizures ( J:75891 )

abnormal nervous system electrophysiology ( J:167856 )

• in response to increased current injection, neurons in the lateral amygdala exhibit more spikes compared with wild-type cells

abnormal afterhyperpolarization ( J:167856 )

• mice exhibit smaller postburst aftethyperpolarization compared to in wild-type mice

homeostasis/metabolism

decreased core body temperature ( J:106453 )

• Background Sensitivity: drop in core body temperature is moderate on a mixed background compared to other genetic backgrounds

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:167856 )

N • mice exhibit normal auditory brainstem response

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
chromosome 1p36 deletion syndrome		DOID:0060410	OMIM:607872	J:167856