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Phenotypes Associated with This Genotype
Genotype
MGI:3619388
Allelic
Composition		 Ins1tm1Jja/Ins1tm1Jja
Tg(Ins2*Y16A)1Ell/0
Genetic
Background		 NOD.Cg-Ins1tm1Jja Tg(Ins2*Y16A)1Ell
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ins1tm1Jja mutation (5 available); any Ins1 mutation (46 available)
Tg(Ins2*Y16A)1Ell mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to autoimmune diabetes ( J:98583 )
• 75% of female transgenic mice lacking Ins2 develop diabetes (2 consecutive blood glucose measurements of >250 mg/dl) by 25 weeks of age

homeostasis/metabolism
increased circulating glucose level ( J:98583 )
• >250 mg/dl blood glucose is considered diabetic

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
type 1 diabetes mellitus DOID:9744 OMIM:222100
 J:98583

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory