Phenotypes Associated with This Genotype

Genotype
MGI:3619388

• Allelic Composition: Ins1^tm1Jja/Ins1^tm1Jja; Tg(Ins2*Y16A)1Ell/0
• Genetic Background: NOD.Cg-Ins1^tm1Jja Tg(Ins2*Y16A)1Ell

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased susceptibility to autoimmune diabetes ( J:98583 )

• 75% of female transgenic mice lacking Ins2 develop diabetes (2 consecutive blood glucose measurements of >250 mg/dl) by 25 weeks of age

homeostasis/metabolism

increased circulating glucose level ( J:98583 )

• >250 mg/dl blood glucose is considered diabetic

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:98583