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Phenotypes Associated with This Genotype
Genotype
MGI:3619409
Allelic
Composition		 Tg(Ins2*Y16A)3Ell/0
Genetic
Background		 NOD-Tg(Ins2*Y16A)3Ell
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Ins2*Y16A)3Ell mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to autoimmune diabetes ( J:98583 )
• 15% of female mice carrying this transgene develop diabetes in the presence of native insulin genes by 35 weeks of age

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
type 1 diabetes mellitus DOID:9744 OMIM:222100
 J:98583

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory