Phenotypes Associated with This Genotype

Genotype
MGI:3619915

• Allelic Composition: Nr4a2^tm1Omc/Nr4a2⁺
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal midbrain development ( J:106612 )

• significantly reduced (39%) dopaminergic neurons in the substantia nigra and ventral tegmental area

behavior/neurological

impaired coordination ( J:104902 )

• rotarod performance reduced 32% at 15-19 months of age

• rotarod performance reduced 39% at 20-24 months of age

abnormal locomotor activation ( J:104902 )

• increased locomotor performance at 2-10 months of age by 29-48%

• decreased locomotor performance by 27-50% after 15 months of age

homeostasis/metabolism

decreased dopamine level ( J:104902 )

• levels normal at 2-10 months of age

• reduced 32% at 15-19 months and 42% at 20-24 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Parkinson's disease		DOID:14330	OMIM:PS168600	J:104902