Phenotypes Associated with This Genotype

Genotype
MGI:3620031

• Allelic Composition: Clip2^tm1.1Gal/Clip2⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:78711 )

• adult female weight is 9% lower than in wild-type

postnatal growth retardation ( J:78711 )

• mild growth retardation during the first weeks of postnatal development that persists in adult females

nervous system

decreased corpus callosum size ( J:78711 )

• average corpus callosum volume is smaller, however ventricle volumes are normal

impaired synaptic plasticity ( J:78711 )

• synaptic plasticity in the hippocampal CA1 region is lower

behavior/neurological

abnormal contextual conditioning behavior ( J:78711 )

• in a contextual fear-conditioning test, show a smaller increase in average freezing time after foot shock than in wild-type, however no differences are seen in a cued fear-conditioning test or elevated zero-maze test, indicating hippocampal defects

impaired coordination ( J:78711 )

• remain on an accelerating rotarod for significantly shorter periods

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Williams-Beuren syndrome		DOID:1928	OMIM:194050	J:78711