muscle
• isolated muscle sarcoplasmic reticulum vesicles have a significant reduction in Ca2+ loading at 37 degrees C and voltage dependent Ca2+ release is shifted toward more negative voltages in isolate myotubes
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• the soleus muscle is more sensitive to caffeine-induced activation in an in vitro contracture test
• increasing the temperature to 41 degrees C for 15 min or less induces full body contractures with agonal breathing, rigid extremities, and arched backs
• isolated muscles display increased basal tension between 35-36 degrees C (43-44 degrees C for the diaphragm)
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homeostasis/metabolism
• during heat induced contractures serum potassium and creatine kinase levels increase by 80% and 163% respectively compared to pre-heat challenge levels suggesting rhabdomyolysis has occurred, no such increase is seen in wild-type mice after heating
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• after heat challenge (increased external temperature to 41 degrees C for less than 15 min) body temperature increases to 43.4 +/- 0.8 degrees C compared to 41.1 +/- 0.3 degrees C in wild-type mice
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behavior/neurological
• exposure to about 5.5 x 10-5 ml/cm3 isoflurane induces a rapid onset of malignant hyperthermic response with full body contractures and increased core temperatures
• increasing the room temperature from less than 25 degrees C to 30 degrees C increases the penetrance of the malignant hyperthermic response
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
malignant hyperthermia | DOID:8545 |
OMIM:PS145600 |
J:105738 |