Phenotypes Associated with This Genotype

Genotype
MGI:3620093

• Allelic Composition: Chm^tm1.1Seab/Chm^tm1.1Seab; Tg(Six3-cre)69Frty/0
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal retina morphology ( J:105458 )

♀ • no depigmentation in the retinal pigment layer

short photoreceptor outer segment ( J:105458 )

♀ • significantly shorter than normal

thin retina outer nuclear layer ( J:105458 )

♀ • 7-8 nuclei thick at 2 months of age

♀ • 4-5 nuclei thick at 4 months of age

abnormal rod electrophysiology ( J:105458 )

♀ • single flash electroretinography shows the loss of "a" waves

nervous system

short photoreceptor outer segment ( J:105458 )

♀ • significantly shorter than normal

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
choroideremia		DOID:9821	OMIM:303100	J:105458