Phenotypes Associated with This Genotype

Genotype
MGI:3620108

• Allelic Composition: Flt4^Chy/Flt4⁺
• Genetic Background: involves: C3H

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Defective lymphatic vessels in the Flt4^Chy/Flt4⁺ mice

mortality/aging

postnatal lethality ( J:72387 )

• the 10% of pups with severe chylous ascites die before weaning

homeostasis/metabolism

edema ( J:177405 )

• in 50% of mice at E15.5

extremity edema ( J:13981 )

• at weaning the hind feet are swollen and edematous

lymphedema ( J:72387 )

chylous ascites ( J:13981 , J:72387 )

• milky fluid accumulates in the abdomen after their first feeding (J:13981)

• chylous ascites are seen in all embryos with about 10% developing severe fluid accumulation and dying, the rest spontaneously resorb the fluid and appear healthy after weaning (J:72387)

immune system

abnormal lymph circulation ( J:72387 )

• dye injected into the hind foot pad fails to be transported into deeper lymphatic vessels

abnormal lymphatic vessel morphology ( J:72387 )

• lymphatic vessels in the intestinal submucosa are enlarged

• lymphatic vessels are mostly absent from the skin with only a few enlarged cutaneous vessels present; however, viral overexpression of Flt4 ligand can induce lymphatic vessel development

abnormal lymphangiogenesis ( J:177405 )

• mice lack lymphatic vessel growth towards the dorsal central line with few enlarged lymphatic vessels around the forelimb skin

liver/biliary system

abnormal liver morphology ( J:72387 )

• mice with severe fluid accumulation also have histopathological changes in the liver

digestive/alimentary system

abnormal intestine morphology ( J:72387 )

• mice with severe fluid accumulation also have fibrinous adhesions in the intestinal tract

adipose tissue

abnormal adipose tissue distribution ( J:72387 )

• the subcutaneous adipose tissue is thickened

reproductive system

reproductive system phenotype ( J:13981 )

N • both sexes are fertile

cardiovascular system

abnormal lymph circulation ( J:72387 )

• dye injected into the hind foot pad fails to be transported into deeper lymphatic vessels

integument

thick dermal layer ( J:72387 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hereditary lymphedema		DOID:0050580	OMIM:PS153100	J:72387