Phenotypes Associated with This Genotype

Genotype
MGI:3620118

• Allelic Composition: Stat4^tm1Gru/Stat4^tm1Gru; Tg(Ins2-NP)25-3Olds/0
• Genetic Background: involves: 129S2/SvPas * BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

insulitis ( J:107047 )

• mutants have a lower degree of insulitis

abnormal cytotoxic T cell physiology ( J:107047 )

• a 5-fold reduction in LCMV-specific CTL precursors is seen after viral challenge with LCMV

decreased interferon-gamma secretion ( J:107047 )

• splenocytes are unresponsive to IL-12 stimulation and do not produce significant levels oi IFNgamma

decreased susceptibility to autoimmune diabetes ( J:107047 )

• a significant reduction in CD4+ T cell-dependent (2 consecutive measures of blood glucose >250 mg/dl) diabetes incidence is observed in mutants (30%) versus controls (85%) when infected with LCMV to induce IDDM

endocrine/exocrine glands

insulitis ( J:107047 )

• mutants have a lower degree of insulitis

hematopoietic system

abnormal cytotoxic T cell physiology ( J:107047 )

• a 5-fold reduction in LCMV-specific CTL precursors is seen after viral challenge with LCMV

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:107047