Phenotypes Associated with This Genotype

Genotype
MGI:3620137

• Allelic Composition: B2m^tm1Unc/B2m^tm1Unc; Ciita^tm1Ccum/Ciita^tm1Ccum
• Genetic Background: NOD.Cg-B2m^tm1Unc Ciita^tm1Ccum

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal glucose homeostasis ( J:107051 )

• NOD diabetic female mice which receive islet grafts from these classI/II-deficient NOD mice remain euglycemic for up to 147 days, compared to mice receiving islet grafts from NOD or class II-deficient NOD mice which maintain euglycemia for only 6-8 days after transplant; upon removal of the graft-bearing kidney, hyperglycemia returned within 24 hours

hematopoietic system

decreased single-positive T cell number ( J:107051 )

• a significant reduction of CD4+ and CD8+ T cells in the periphery is observed in these animals

immune system

decreased single-positive T cell number ( J:107051 )

• a significant reduction of CD4+ and CD8+ T cells in the periphery is observed in these animals

decreased susceptibility to autoimmune diabetes ( J:107051 )

• mice monitored to 30 weeks of age do not develop type I diabetes (2 consecutive blood glucose readings >16.5nM) while 70% of wild-type NOD mice develop diabetes

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	type 1 diabetes mellitus	DOID:9744	OMIM:222100	J:107051