Phenotypes Associated with This Genotype

Genotype
MGI:3620217

• Allelic Composition: Tcra^tm1Mom/Tcra^tm1Mom
• Genetic Background: B6.129S2-Tcra^tm1Mom

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

colitis ( J:135597 )

• a disease similar to ulcerative colitis occurs in these mice with histology revealing inflammation and elongation of the crypts

increased mature gamma-delta T cell number ( J:135597 )

• there are 20-fold more gammadelta T cells found in the lamina propia of the gut compared to wild-type mice

increased susceptibility to bacterial infection ( J:106241 )

• greatly increased susceptibility to infection with Mycobacterium paratuberculosis

abnormal response to transplant ( J:91742 )

• mice fail to reject tail skin from OVA expressing transgenic mice ( Tg(CAG-OVA)916Jen )

digestive/alimentary system

abnormal large intestine morphology ( J:135597 )

• colitis results in lengthening of the colon

• the large intestine weight to body weight ratio at 28 weeks of age is twice as great than what is observed in wild-type mice

rectal prolapse ( J:135597 )

• rectal prolapse occurs in about 18% of mice 24 to 60 weeks of age

colitis ( J:135597 )

• a disease similar to ulcerative colitis occurs in these mice with histology revealing inflammation and elongation of the crypts

hematopoietic system

increased mature gamma-delta T cell number ( J:135597 )

• there are 20-fold more gammadelta T cells found in the lamina propia of the gut compared to wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
inflammatory bowel disease		DOID:0050589	OMIM:PS266600	J:135597