Analysis Tools
nervous system
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• increased numbers of microglia accompany degenerative changes
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microgliosis
(
J:245100
)
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• microgliosis in the hippocampal fimbria at 26 weeks of age
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• hippocampal fimbria exhibits APP+ axonal spheroids, microgliosis and astrogliosis
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• mild astrocytosis accompanies degenerative changes
(J:48031)
• moderate, but significant, astrogliosis in the hippocampal fimbria at 26 weeks of age
(J:245100)
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• occasionally inner tongue processes of pligdendrocytes contain degenerated organelles
(J:48031)
• primary glial cultures have increased numbers of oligodendrocytes starting at the second division and persisting through at least the fourteenth division; however no increase in oligodendrocyte proliferation is seen
(J:106182)
• in primary glial cultures oligodendrocyte sheets appear larger, vacuolated, and broken suggesting decreased stability of the myelin sheet
(J:106182)
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• at 6 - 8 weeks, focal axonal swellings containing organelles are seen mostly in areas where small diameter axons predominate throughout the white and gray matter
• by 1 year, numerous large axonal swellings are seen in the optic nerve and spinal cord with some also seen in Purkinje cell axons
• after 1 year, axonal degeneration is seen in the optic nerve and fasciculus gracilis; however, no signs of peripheral neuropathy are seen
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• in areas of axonal swelling the myelin sheath becomes attenuated and is eventually lost though slippage
(J:48031)
• decrease in cholesterol content
(J:193310)
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• APP+ axonal spheroids are present in the hippocampal fimbria and corpus callosum at 26 weeks of age
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demyelination
(
J:48031
)
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• evidence of demyelination is seen at 22 months of age
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behavior/neurological
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• at 16 months of age impaired performance in a rotarod test is seen
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• at 16 months of age impaired performance in a rotarod test is seen
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abnormal gait
(
J:48031
)
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• older mice develop a slow gait
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hematopoietic system
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• increased numbers of microglia accompany degenerative changes
|
microgliosis
(
J:245100
)
|
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• microgliosis in the hippocampal fimbria at 26 weeks of age
|
immune system
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• increased numbers of microglia accompany degenerative changes
|
microgliosis
(
J:245100
)
|
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• microgliosis in the hippocampal fimbria at 26 weeks of age
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homeostasis/metabolism
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• in myelin
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| hereditary spastic paraplegia 2 | DOID:0110773 |
OMIM:312920 |
J:48031 , J:245100 | |
