Phenotypes Associated with This Genotype

Genotype
MGI:3620464

cx1

• Allelic Composition: Tg(CSF2)2Ygy/0; Tg(IL3)1Ygy/0; Tg(KITLG)3Ygy/0
• Genetic Background: C.Cg-Tg(CSF2)2Ygy Tg(IL3)1Ygy Tg(KITLG)3Ygy

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal response to transplant ( J:107052 )

• low levels of porcine chimerism are detected in the blood of recipent mice at 1 week, but all detectable chimerism in the blood is lost by 2 weeks;at 19-22 weeks after transplant, no chimerism is detected in the spleen or bone marrow

decreased susceptibility to graft versus host disease ( J:107052 )

• conditioned mice were injected with splenocytes, or PBMC and BMC from sensitized porcine donors, no recipients showed detectable GVHD