Phenotypes Associated with This Genotype

Genotype
MGI:3620543

• Allelic Composition: Maoa^{Tg(H2-K1-Ifnb1)8Seif}/Y
• Genetic Background: involves: C3H/HeJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased dopamine level ( J:26232 )

♂ • mutants show increased levels of dopamine in their brains

increased noradrenaline level ( J:26232 )

♂ • mutants have elevated noradrenaline levels in the brain

increased serotonin level ( J:26232 )

♂ • mutants have elevated serotonin levels in their brains

behavior/neurological

abnormal behavior ( J:26232 )

♂ • in the open field test, adult mutants spend increased time in the center with hesitation about which direction to take (although if this is due to sensory or cognitive deficits or reduced fear is not known); for 12-week old mice, male mutants spent significantly greater time in the center than did controls

♂ • between days 11 and 16, animals run frantically and fall over

abnormal eating behavior ( J:26232 )

♂ • i.p. injection of MAOB inhibitors into adult mutants disrupts feeding

increased aggression towards humans ( J:26232 )

♂ • between days 11 and 16, animals have a greater tendency to bite the experimenter

abnormal depression-related behavior ( J:26232 )

♂ • in the Porsolt's swim test, adult mutants make persistent attempts to escape, whereas controls spend more time floating; 9-week old male mutants spend significantly reduced time immobile in the water compared to control C3H animals

increased fear-related response ( J:26232 )

♂ • between days 11 and 16, animals promptly dig to hide under shavings in response to moderate sound and movement

abnormal grooming behavior ( J:26232 )

♂ • i.p. injection of MAOB inhibitors into adult mutants disrupts self-grooming

abnormal motor coordination/balance ( J:26232 )

♂ • between days 5 and 10, when placed on a new surface, animals move backward instead of pivoting

impaired righting response ( J:26232 )

♂ • between days 5 and 10, animals display prolonged righting compared to C3H controls

impaired balance ( J:26232 )

♂ • in a beam-walking test, adult mutants grasp the edge of the beam with their hindlimbs whereas C3H adults are sure footed

hunched posture ( J:26232 )

♂ • between days 11 and 16, mice have a hunched posture

head bobbing ( J:26232 )

♂ • neonates display intense head nodding behavior

abnormal sleep pattern ( J:26232 )

♂ • between days 11 and 16, sleep is accompanied by violent shaking and jumps dispersing littermates

hyperresponsive ( J:26232 )

♂ • between days 5 and 10, animals display prolonged, stronger reactions to pinching

abnormal social/conspecific interaction behavior ( J:26232 )

♂ • i.p. injection of MAOB inhibitors into adult mutants disrupts social interaction

increased aggression towards male mice ( J:26232 )

♂ • in 6-12 week old animals, males housed in groups from time of weaning display offensive aggressive behavior, signified by bite wounds on genitals and rump: wounds are most apparent at 3 months of age

abnormal sexual interaction ( J:26232 )

♂ • when males are placed with a nonreceptive female for 30 minutes, courtship is disrupted by episodes of grasping reflected by increased female squeaking compared with control C3H male courtship behavior

abnormal social investigation ( J:26232 )

♂ • in resident-intruder paradigms, mutant males attacked intruders faster than C3H controls which displayed intense social investigation and home cage checking initially

nervous system

abnormal cerebral cortex morphology ( J:26232 )

♂ • somatosensory cortex of male mutant pups and adults display complete absence of cylindrical aggregates of granule cells (barrels) in layer IV

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Brunner Syndrome		DOID:0060693	OMIM:300615	J:26232