Phenotypes for Prph2 MGI:3620587 MGI Mouse

abnormal eye development ( J:25582 )

• at P14, considerable portions of the retinal surface have fewer outer segments and those present have disc structures that are irregularly oriented

abnormal retina layer morphology ( J:25582 )

abnormal retina photoreceptor morphology ( J:25582 )

• at 18 months, some photoreceptor synaptic terminals have multiple synaptic ribbons

increased retina cone cell number ( J:25582 )

• the percentage of cones in the retina increases from 6 months on, with greater increases in the periphery than in the center of the retina

abnormal photoreceptor inner segment morphology ( J:25582 )

• occasional inner segments with swollen endoplasmic reticuli and vacuoles

abnormal photoreceptor outer segment morphology ( J:25582 )

• outer segments are delayed in development but eventually appear throughout the retinal surface

• outer segments are reduced in length and morphologically abnormal appearing as round masses present from the apical end of the inner segments to the pigment epthelial villous processes

• these round masses contain irregular whorls of disc membranes that appear to be swollen and vacuolated

• at 18 months, outer segments become reduced and somewhat patchy

abnormal retina pigment epithelium morphology ( J:25582 )

• pigment epithelial cells contain larger and more numerous phagosomes

• peak turnover of phagosomes during the light dark cycle is shifted towards the end of the light period

thin retina outer nuclear layer ( J:25582 )

• maximal outer nuclear layer thickness is only 50-60% of wild-type

• at 18 months, outer nuclear layer thickness is markedly decreased

• thinning of the outer nuclear layer is first seen in the peripheral retina and later seen in the central retina