Phenotypes Associated with This Genotype

Genotype
MGI:3620917

• Allelic Composition: Lmna^tm1Stw/Lmna⁺
• Genetic Background: involves: 129S1/Sv * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating insulin level ( J:75101 )

• on a high fat diet, females develop mild insulin resistance that correlates with increased body weight, no insulin resistance is seen in males

• on a normal diet, serum glucose, insulin, and triglyceride levels are normal, insulin sensitivity and glucose tolerance

insulin resistance ( J:75101 )

• on a high fat diet, females develop increased insulin but not glucose levels

adipose tissue

adipose tissue phenotype ( J:75101 )

N • no signs of lipoatrophy are seen

liver/biliary system

liver/biliary system phenotype ( J:75101 )

N • liver morphology is normal

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	familial partial lipodystrophy	DOID:0050440	OMIM:PS151660	J:75101