mortality/aging
• treatment with an FTI increased the survival of both male and female mutants significantly compared with vehicle-treated mutant controls; by 20 weeks of age, 6 of 14 vehicle-treated mutants had died, but only 1 of 13 FTI-treated mutants was dead
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growth/size/body
• male and female mutant mice treated with an FTI gain more weight than vehicle treated controls
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skeleton
• at 20 weeks, the median number of rib fractures in FTO-treated mice is 2, compared to 14 in vehicle treated mice
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behavior/neurological
• 100% of male and female mutant mice receiving vehicle exhibit abnormal grip strength by 16 weeks of age; only 28% of female and 33% of male mutants receiving a farnesyltransferase inhibitor (FTI) show a grip abnormality in a grid-hang test
• the delay in appearance of grip abnormalities is significant for male and female mutants
• the mean length of hang time of inhibitor-treated mice is longer than for vehicle treated mice
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
progeria | DOID:3911 |
OMIM:176670 |
J:106706 |