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Phenotypes Associated with This Genotype
Genotype
MGI:3620988
Allelic
Composition
Zmpste24tm1Sgy/Zmpste24tm1Sgy
Genetic
Background
B6.129S4-Zmpste24tm1Sgy
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zmpste24tm1Sgy mutation (2 available); any Zmpste24 mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• treatment with an FTI increased the survival of both male and female mutants significantly compared with vehicle-treated mutant controls; by 20 weeks of age, 6 of 14 vehicle-treated mutants had died, but only 1 of 13 FTI-treated mutants was dead

growth/size/body
• male and female mutant mice treated with an FTI gain more weight than vehicle treated controls

skeleton
• at 20 weeks, the median number of rib fractures in FTO-treated mice is 2, compared to 14 in vehicle treated mice

behavior/neurological
• 100% of male and female mutant mice receiving vehicle exhibit abnormal grip strength by 16 weeks of age; only 28% of female and 33% of male mutants receiving a farnesyltransferase inhibitor (FTI) show a grip abnormality in a grid-hang test
• the delay in appearance of grip abnormalities is significant for male and female mutants
• the mean length of hang time of inhibitor-treated mice is longer than for vehicle treated mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
progeria DOID:3911 OMIM:176670
J:106706


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory