Phenotypes Associated with This Genotype

Genotype
MGI:3620990

hm1

• Allelic Composition: Bmpr2^tm1Kmi/Bmpr2^tm1Kmi
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:61931 )

• at E6.5-E8.5, homozygotes are recovered at the expected Mendelian frequency but appear abnormal

• no homozygotes are recovered at E9.5

embryo

failure to gastrulate ( J:61931 )

• homozygotes fail to undergo normal gastrulation

abnormal rostral-caudal axis patterning ( J:61931 )

• at E7.5, homozygotes lack a properly established A-P axis

embryonic growth arrest ( J:61931 )

• homozygotes are arrested at the egg cylinder stage before gastrulation

embryonic growth retardation ( J:61931 )

• at E6.5, homozygotes exhibit progressive growth retardation and are significantly smaller than wild-type embryos

abnormal embryonic epiblast morphology ( J:61931 )

• at E6.5 and E7.5, homozygotes display impaired epiblast differentiation; in contrast, expression of tissue-specific genes for visceral endoderm differentiation is relatively normal

decreased egg cylinder size ( J:61931 )

• at E6.5, homozygotes fail to form elongated egg cylinders

absent mesoderm ( J:61931 )

• at E7.5, homozygous mutant embryos lack a mesoderm layer

failure of primitive streak formation ( J:61931 )

• at E7.5, homozygotes lack a morphologically identifiable primitive streak

disorganized embryonic tissue ( J:61931 )

abnormal embryonic-extraembryonic boundary morphology ( J:61931 )

• at E6.5, homozygous mutant embryos are disorganized and lack a clear distinction between the embryonic and extraembryonic portions

disorganized extraembryonic tissue ( J:61931 )

growth/size/body

embryonic growth retardation ( J:61931 )

• at E6.5, homozygotes exhibit progressive growth retardation and are significantly smaller than wild-type embryos