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Phenotypes Associated with This Genotype
Genotype
MGI:3621559
hm1
Allelic
Composition		 Ptpn11tm1Paw/Ptpn11tm1Paw
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptpn11tm1Paw mutation (0 available); any Ptpn11 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
polyploidy ( J:106624 )
• cultured trophoblast stem cells exhibit an increase in ploidy under differentiating conditions
abnormal cell death ( J:106624 )
• null trophoblast stem cells die rapidly in culture
decreased cell proliferation ( J:106624 )
• mutation causes decreased trophoblast stem cell proliferation and colony formation in culture

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
08/05/2025
MGI 6.24 		The Jackson Laboratory