Phenotypes Associated with This Genotype

Genotype
MGI:3621567

• Allelic Composition: Erbb2^tm1Cbm/Erbb2^tm2Cbm; Myl2^tm1(cre)Krc/Myl2⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:77347 )

• 27% die before reaching 6 months of age and 20% die during echochardiographic or ECG examination

postnatal lethality, incomplete penetrance ( J:77347 )

• 16% die within the first 2 weeks, the rest reach adulthood

cardiovascular system

abnormal myocardial fiber morphology ( J:77347 )

• adults and 3 month old mice exhibit myofiber hypertrophy

• frequently observe enlarged cardiomyocyte nuclei with abnormal morphology

cardiac hypertrophy ( J:77347 )

• heart-to-body weight ratios of adults are increased by 26%, indicative of hypertrophy

increased heart ventricle size ( J:77347 )

• adults exhibit enlarged ventricular chambers

thin ventricular wall ( J:77347 )

• seen in adults

dilated cardiomyopathy ( J:77347 )

• progressive malfunction of the heart

decreased heart ventricle muscle contractility ( J:77347 )

• at 3 months of age, ventricular diameter is increased and fractional shortening is impaired

• hearts do not compensate after aortic banding but display a further decrease in fractional shortening

decreased heart left ventricle muscle contractility ( J:77347 )

• at 1 month of age, see dilatation and loss of left ventricle contractility

prolonged QT interval ( J:77347 )

• significantly lengthened QT_c interval caused by a slowed ventricular repolarization

muscle

abnormal myocardial fiber morphology ( J:77347 )

• adults and 3 month old mice exhibit myofiber hypertrophy

• frequently observe enlarged cardiomyocyte nuclei with abnormal morphology

dilated cardiomyopathy ( J:77347 )

• progressive malfunction of the heart

decreased heart ventricle muscle contractility ( J:77347 )

• at 3 months of age, ventricular diameter is increased and fractional shortening is impaired

• hearts do not compensate after aortic banding but display a further decrease in fractional shortening

decreased heart left ventricle muscle contractility ( J:77347 )

• at 1 month of age, see dilatation and loss of left ventricle contractility

growth/size/body

cardiac hypertrophy ( J:77347 )

• heart-to-body weight ratios of adults are increased by 26%, indicative of hypertrophy

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
dilated cardiomyopathy		DOID:12930	OMIM:PS115200	J:77347