Phenotypes Associated with This Genotype

Genotype
MGI:3622093

• Allelic Composition: Alms1^foz/Alms1^foz
• Genetic Background: involves: NOD

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

hyperglycemia ( J:107058 )

• female mice are diabetic by 200 days of age

increased circulating insulin level ( J:107058 )

• female mice develop insulinemia (20ng/mL insulin vs. 2-5ng/mL in wild-type)

insulin resistance ( J:107058 )

• female mice develop insulin resistance by 200 days of age

behavior/neurological

increased food intake ( J:107058 )

• mutants eat more than wild-type

liver/biliary system

enlarged liver ( J:107058 )

• mice fed high-fat diet show hepatomegaly compared to wild-type (8.9g vs. 2g)

increased liver weight ( J:107058 )

• liver weights in mutant are twice that of wild-type (3.4g vs. 1.6g)

abnormal hepatocyte morphology ( J:107058 )

• mutant livers show many hepatocytes with ballooning degeneration and extensive lobular inflammation with polymorphs and mononuclear cells

hepatic steatosis ( J:107058 )

• chow-fed mutants develop steatosis; mutants fed the high-fat diet develop severe steatohepatitis

liver fibrosis ( J:107058 )

• mutant livers show pericellular and pericentral fibrosis

growth/size/body

enlarged liver ( J:107058 )

• mice fed high-fat diet show hepatomegaly compared to wild-type (8.9g vs. 2g)

increased liver weight ( J:107058 )

• liver weights in mutant are twice that of wild-type (3.4g vs. 1.6g)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alstrom syndrome		DOID:0050473	OMIM:203800	J:107058