Phenotypes Associated with This Genotype

Genotype
MGI:3622193

• Allelic Composition: Ppp1r15a^tm1.1Ajf/Ppp1r15a^tm1.1Ajf
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

increased spleen weight ( J:106905 )

• spleen weight and spleen to brain ratio are increased

hematopoietic system

increased spleen weight ( J:106905 )

• spleen weight and spleen to brain ratio are increased

abnormal erythrocyte morphology ( J:106905 )

abnormal erythropoiesis ( J:106905 )

• the induction of erythrocyte hyperplasia when placed on an iron deficient diet is delayed compared to wild-type mice

decreased hemoglobin content ( J:106905 )

• decreased hemoglobin content but normal hematocrit

decreased mean corpuscular hemoglobin ( J:106905 )

• mean corpuscular hemoglobin is decreased on a normal chow diet

• the recovery time for mean corpuscular hemoglobin to return to baseline after 8 weeks on an iron deficient diet is increased compared about 2-fold to wild-type mice

decreased mean corpuscular volume ( J:106905 )

• mean corpuscular volume is decreased on a normal chow diet

• the recovery time for mean corpuscular volume to return to baseline after 8 weeks on an iron deficient diet is increased about 2-fold compared to wild-type mice

acanthocytosis ( J:106905 )

• abnormal red blood cells with small, evenly spaced protrusions (spiculocytes) are observed

anisopoikilocytosis ( J:106905 )

• increase in the range of red blood cell size and presence of abnormally shaped red blood cells

increased number of Howell-Jolly bodies ( J:106905 )

• abnormal red blood cells with nucleic acid remnants (Howell-Jolly bodies) are observed

leptocytosis ( J:106905 )

• abnormal red blood with a darkly stained center surrounded by a pale area (target cells) are observed

microcytosis ( J:106905 )

abnormal splenic cell ratio ( J:106905 )

• decreased percentage of mature erythroid precursors and enrichment of nucleated, immature cells in the red pulp

decreased erythrocyte osmotic fragility ( J:106905 )

• erythrocytes are more resistant to lysis in hypotonic solutions compared to wild-type cells

immune system

increased spleen weight ( J:106905 )

• spleen weight and spleen to brain ratio are increased

abnormal splenic cell ratio ( J:106905 )

• decreased percentage of mature erythroid precursors and enrichment of nucleated, immature cells in the red pulp

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
thalassemia		DOID:10241		J:106905