Phenotypes Associated with This Genotype

Genotype
MGI:3622312

• Allelic Composition: Il1r1^tm1Roml/Il1r1^tm1Roml
• Genetic Background: NOD.Cg-Il1r1^tm1Roml

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell death ( J:87251 )

• islets isolated from mutant mice show decreased cell death in response to treatment with Il-1 and IFN gamma

immune system

decreased susceptibility to autoimmune diabetes ( J:87251 )

• spontaneous diabetes (blood glucose >12 mmol/l) is delayed in mutants slightly but significantly in female knockouts kept to 350 days of age

• adoptive tranfer of splenocytes from transgenic mice carrying the Tg(TcraBDC2.5)1Doi transgene into knockout recipients led to diabetes after a significant delay compared to diabetes development in wild-type recipients (100% in wild-type by 12 days versus 100% in knockouts by 20 days)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:87251