Phenotypes Associated with This Genotype

Genotype
MGI:3622322

cx3

• Allelic Composition: Tg(Ins2-HA)165Bri/0; Tg(TcraCl4,TcrbCl4)1Shrm/0
• Genetic Background: involves: BALB/c * C57BL/6 * C57BL/10 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality ( J:99756 )

• neonates die within 7-10 days of birth

homeostasis/metabolism

hyperglycemia ( J:99756 )

• neonates exhibit hyperglycemia

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:99756 )

• animals display a loss of islet mass and dissemination of remaining islet beta-cell clusters

insulitis ( J:99756 )

• In 1-day-old animals, there are many infiltrating cells in the islet and peri-islet regions

immune system

insulitis ( J:99756 )

• In 1-day-old animals, there are many infiltrating cells in the islet and peri-islet regions