Phenotypes Associated with This Genotype

Genotype
MGI:3622418

• Allelic Composition: Il4^tm1Cgn/Il4^tm1Cgn
• Genetic Background: NOD.Cg-H2^b Il4^tm1Cgn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal enzyme/coenzyme activity ( J:105803 )

• amylase activity increases slightly between 4 and 20 weeks of age(181 to 250 U/L) compared to activity in wild-type which decreases (386 to 288 U/L)

• parotid secretory protein protease activity is retained in mutants while non-diseased animals do not show activity

endocrine/exocrine glands

abnormal salivary gland physiology ( J:105803 )

• mice do not exhibit a decrease in salivary flow rates compared to NOD.B10-H2b mice at 4 weeks of age; normal salivary flow is retained to 36 weeks of age compared to controls

• saliva maintains normal protein concentrations compared to NOD and NOD.B10-H2b controls

salivary gland inflammation ( J:105803 )

• foci of leukocytic infiltration contain more T cells than NOD.B10-H2b controls

lacrimal gland inflammation ( J:105803 )

• foci of leukocytic infiltration contain more T cells than NOD.B10-H2b controls

immune system

salivary gland inflammation ( J:105803 )

• foci of leukocytic infiltration contain more T cells than NOD.B10-H2b controls

lacrimal gland inflammation ( J:105803 )

• foci of leukocytic infiltration contain more T cells than NOD.B10-H2b controls

vision/eye

lacrimal gland inflammation ( J:105803 )

• foci of leukocytic infiltration contain more T cells than NOD.B10-H2b controls

digestive/alimentary system

abnormal salivary gland physiology ( J:105803 )

• mice do not exhibit a decrease in salivary flow rates compared to NOD.B10-H2b mice at 4 weeks of age; normal salivary flow is retained to 36 weeks of age compared to controls

• saliva maintains normal protein concentrations compared to NOD and NOD.B10-H2b controls

salivary gland inflammation ( J:105803 )

• foci of leukocytic infiltration contain more T cells than NOD.B10-H2b controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Sjogren's syndrome		DOID:12894	OMIM:270150	J:105803