Phenotypes Associated with This Genotype

Genotype
MGI:3622480

• Allelic Composition: Tg(Fabp4-Hsd11b1)7Jesf/0
• Genetic Background: FVB-Tg(Fabp4-Hsd11b1)7Jesf

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

obese ( J:107046 )

• develop visceral obesity that is further exaggerated by a high-fat diet

increased susceptibility to weight gain ( J:107046 )

• body weights diverge after 9 weeks of age and by 15 weeks, mutants weigh 16% more than controls

increased susceptibility to diet-induced obesity ( J:107046 )

• exhibit an increase in sensitivity to weight gain on a high-fat diet, with a 24% weight gain vs. 16% in controls

adipose tissue

abnormal adipose tissue distribution ( J:107046 )

• small increase in subcutaneous abdominal adipose tissue and a striking increase in mesenteric adipose tissue, however no differences in epididymal adipose tissue

• disproportionate accumulation of visceral fat depots

increased fat cell size ( J:107046 )

• adipocyte size in mesenteric or subcutaneous abdominal fat depots is increased 3.2-fold and 1.5-fold, respectively

behavior/neurological

polyphagia ( J:107046 )

• 10.2% increase in food intake

homeostasis/metabolism

increased susceptibility to diet-induced obesity ( J:107046 )

• exhibit an increase in sensitivity to weight gain on a high-fat diet, with a 24% weight gain vs. 16% in controls

increased circulating leptin level ( J:107046 )

• leptin levels are disproportionately elevated, suggesting the development of leptin resistance

abnormal glucose homeostasis ( J:107046 )

hyperglycemia ( J:107046 )

increased circulating insulin level ( J:107046 )

impaired glucose tolerance ( J:107046 )

insulin resistance ( J:107046 )

• exhibit insulin-resistant diabetes

abnormal lipid homeostasis ( J:107046 )

increased circulating triglyceride level ( J:107046 )

abnormal corticosterone level ( J:107046 )

• corticosterone levels are elevated 15-30% in adipose tissue and are increased 2.7-fold in portal vein, however see no differences in serum levels

increased fatty acids level ( J:107046 )

• 3.3-fold increase in portal vein free fatty acid levels

increased circulating free fatty acids level ( J:107046 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
abdominal obesity-metabolic syndrome 1		DOID:14221	OMIM:605552	J:107046