Phenotypes Associated with This Genotype

Genotype
MGI:3622764

• Allelic Composition: Prf1^tm1Clrk/Prf1^tm1Clrk; Tg(INS-Il10)#Sar/0
• Genetic Background: involves: 129S7/SvEvBrd * BALB/c * NOD

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased susceptibility to autoimmune diabetes ( J:64051 )

• only 11% of animals develop diabetes by 5 weeks of age (blood glucose >300 mg/dl), while 50% of wild-type transgenic animals develop diabetes, but the overall incidence by 12 weeks is the same for both

• mice are considered diabetic after a blood glucose measure of >300 mg/dl

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:64051