Phenotypes Associated with This Genotype

Genotype
MGI:3623009

hm2

• Allelic Composition: Ryr3^tm1Tno/Ryr3^tm1Tno
• Genetic Background: involves: 129S4/SvJae * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired passive avoidance behavior ( J:61004 )

• homozygous mice show poor passive avoidance performance compared to wild-type

abnormal contextual conditioning behavior ( J:61004 )

• after a foot shock on Day 1, homozygotes show no decrease in locomotor activity on Day2 compared to wild-type which show decreased locomotor activity

abnormal spatial learning ( J:61004 )

• homozygous mutant mice display a low level of spontaneous alternation behavior in a Y-maze test compared to wild-type