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Phenotypes Associated with This Genotype
Genotype
MGI:3623373
Allelic
Composition		 Cd4tm1Knw/Cd4tm1Knw
Genetic
Background		 NOD.Cg-Cd4tm1Knw
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd4tm1Knw mutation (3 available); any Cd4 mutation (85 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to autoimmune diabetes ( J:93553 )
• Cd4-deficient mice are diabetes resistant (diabetes observed in 0/18 females by 30 weeks)

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
NOT type 1 diabetes mellitus DOID:9744 OMIM:222100
 J:93553

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory