Phenotypes Associated with This Genotype

Genotype
MGI:3623404

• Allelic Composition: Eng^tm1Hma/Eng⁺
• Genetic Background: 129P2/OlaHsd-Eng^tm1Hma

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal blood vessel morphology ( J:73415 )

• occasional mice exhibit extensive dilated and weak-walled vessels

• elastin support fibers surrounding fragile vessels are disorganized and sparsely distributed

abnormal vascular smooth muscle morphology ( J:73415 )

• smooth muscle cells surrounding the fragile vessels are disorganized and sparsely distributed

muscle

abnormal vascular smooth muscle morphology ( J:73415 )

• smooth muscle cells surrounding the fragile vessels are disorganized and sparsely distributed

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hereditary hemorrhagic telangiectasia		DOID:1270	OMIM:187300 OMIM:600376 OMIM:615506	J:73415