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Phenotypes Associated with This Genotype
Genotype
MGI:3623448
Allelic
Composition		 Ifngtm1Ts/Ifngtm1Ts
Genetic
Background		 NOD.Cg-Ifngtm1Ts Prkdcscid
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ifngtm1Ts mutation (18 available); any Ifng mutation (49 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to autoimmune diabetes ( J:72818 )
• when diabetic NOD splenocytes are transferred into mutant NOD.scid mice only 23% of recipients become diabetic (determined by monitoring urine glucose level) 7 weeks after transfer, but 100% of wild-type NOD.Scid mice are diabetic within 5 weeks

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
type 1 diabetes mellitus DOID:9744 OMIM:222100
 J:72818

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory