Analysis Tools
mortality/aging
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• survive infection with Lymphocytic Choriomeningitis Virus
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immune system
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• numbers increase in parallel to decrease in CD8+ cells
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• 90% reduction of single positive CD8 peripheral T-cells
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• CD8+ TCRalpha/beta T-cells not present
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• survive infection with Lymphocytic Choriomeningitis Virus
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nervous system
| N |
• normal gross cerebellar development
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• increased glutamate transients in climbing fiber synaptic clefts
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• lower threshold for induction if climbing fibers are involved in induction
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• larger paired pulse ratio when paired stimuli are applied to climbing fibers are separated by 50-100 msec
• significantly increased second excitatory postsynaptic current
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behavior/neurological
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• performance in rotarod tests is significantly better than controls on the third day of testing
• testing repeated after 2 weeks of rest and then after another 4 months of rest indicate much better task retention than for controls
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hematopoietic system
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• numbers increase in parallel to decrease in CD8+ cells
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• 90% reduction of single positive CD8 peripheral T-cells
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• CD8+ TCRalpha/beta T-cells not present
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