Phenotypes Associated with This Genotype

Genotype
MGI:3623523

• Allelic Composition: B2m^tm1Unc/B2m^tm1Unc
• Genetic Background: NOD.129P2-B2m^tm1Unc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal pancreatic beta cell morphology ( J:17000 )

• homozygous-null NOD mice show almost no insulitis and still possess normal beta cells; control NOD mice show insulitis and a high degree of beta cell destruction

immune system

absent CD8-positive, alpha-beta T cells ( J:121685 )

• mice lack CD8+ T cells

decreased susceptibility to autoimmune diabetes ( J:17000 , J:121685 )

• no homozygous mice become diabetic by 4 months of age, while over 70% of control NOD mice become diabetic (blood glucose >16.7 mM; positive urine glucose test) by 4 months of age (J:17000)

• females remain disease-free compared (J:121685)

hematopoietic system

absent CD8-positive, alpha-beta T cells ( J:121685 )

• mice lack CD8+ T cells

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	type 1 diabetes mellitus	DOID:9744	OMIM:222100	J:17000